Centiloid Project


 

Amyloid imaging with positron emission tomography (PET), has produced remarkably consistent qualitative findings across a large number of centers; however, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. A common quantitative output value for beta-amyloid imaging applicable across tracers and methods will allow better comparison of data across sites, ultimately resulting in the application of universal diagnostic and prognostic values.

This has driven the creation of a 100-point scale termed “Centiloid,” which is an average value of zero in “high certainty” amyloid negative subjects and an average of 100 in “typical” Alzheimer’s disease (AD) patients (Klunk et al., 2015). Calibration to the Centiloid scale allows units that are more easily compared across sites. All data used in the Centiloid Project is available for download in the pages below.

Standard PiB (PET or DICOM) data:

[F-18] amyloid tracers:

CALIBRATION OF THE STANDARD PiB METHOD

These data can be used to scale global cortical PiB PET SUVr data to the Centiloid standard scale.

This is the basic dataset that most users will employ when doing Level 2 or Level 3 Centiloid scaling analyses. It consists of all of the AD-100 and YC-0 PiB PET 50-70 min data and the corresponding MR data in both DICOM and nifti formats.

AD-100_PET_5070.zip AD-100_MR.zip YC-0_PET_5070.zip YC-0_MR.zip Centiloid_Processing.docx Centiloid_Std_VOI.zip SupplementaryTable1.xlsx Table_1_Centiloid-Paper_11Feb2016.pdf

Full Dynamic Dataset Advanced Users File Names and descriptions

This dataset is intended for users who are seeking to scale PiB PET data that is not 50-70 SUVr to the Centiloid scale. This would include dynamic PiB data (e.g., BPND) and SUVr data from a time period other than 50-70 min. This dataset may allow users to do this without acquiring any new PiB PET data. Users who seek to perform a standard Centiloid scaling analysis should use the 50-70 min dataset.

Disclaimer: This data is intended for users already experienced in the use of dynamic PET data. These users should refer to the “CentiloidPETFraming.xls” file as an aid to determining the framing of each subject dataset.

AD_PET_01-25.zip AD_PET_26-45.zip AD-100_MR.zip YC_PET_101-115.zip YC_PET_116-134.zip YC-0_MR.zip CentiloidPETFraming.xlsx

Supplementary Data Advanced Users File Names and descriptions

This is the data described in section 2.1.2 “The standard VOIs” in the Centiloid Project paper (Klunk et al. Alzheimers Dement 2015;11:1-15). This dataset was used to generate the average AD-CTX and average OC-CTX images - the difference between which at 1.05 SUVr units produced the standard cortical target (CTX) VOI.

AD-CTX_VOI_MR.zip OC-CTX_VOI_MR.zip AD_CTX_VOI_PET.zip OC_CTX_VOI_PET.zip Centiloid_Std_VOI.zip FDG_AD-CTX.zip

Please email here for questions regarding the Centiloid Project.

W. E. Klunk et al., The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers. Dement. 11, 1–4 (2015).


Calibration of F-18 Amyloid Tracers


These data are for standardizing F-18 amyloid tracers that have been calibrated to the Centiloid standard scale.


 

[F-18] Florbetaben (FBB) Calibration


50-70 Minute PIB and 90-110 FBB Dataset (dicom data) File Names and descriptions

The Centiloid method was applied on 18F-FBB (FBB) and 11C-PiB (PiB) Ab images to derive the scaling factor required to express FBB tracer binding in Centiloids (CL). This is the basic dataset that users will use to convert FBB PET SUVR into Centiloid scale. It consists of 50-70 min PIB and 90-110 FBB scans from 25 elderly subjects and 10 young controls and the corresponding MR data in dicom.

FBBproject_E-25_FBB_90110.zip FBBproject_E-25_MR.zip FBBproject_E-25_PIB_5070.zip FBBproject_YC-10_FBB_90110.zip FBBproject_YC-10_MR.zip FBBproject_YC-10_PIB_5070.zip FBBproject_Demographics.xlsx FBBproject_SupplementaryTable.xlsx FBBproject_Table1.xlsx FBBproject_FileDescriptions.txt


Please email here for questions regarding this dataset. More details can be found in the following paper:

18F-Florbetaben PET beta-amyloid binding expressed in Centiloids, Rowe, C.C., Doré, V., Jones, G. et al. Eur J Nucl Med Mol Imaging (2017). doi:10.1007/s00259-017-3749-6

[F-18] Flutemetamol Calibration


50-70 Minute PIB/flutemetamol Dataset (NIFTI and DICOM data)  File Names and descriptions

This is the data set that users will use to convert [18F]flutemetamol PET SUVr into Centiloid scale. [18F]flutemetamol and [11C]PiB images were processed using SPM8 with the standard Centiloid VOIs, following the methods described by Klunk et al, (Alzheimers Dement, 2015).

The datasets consists of 50-70 min PIB and 90-110 min [18F] flutemetamol scans from 17 AD Patients and 23 young healthy controls and the corresponding MR data in both NITI and DICOM.

This dataset can be used to convert [18F]flutemetamol PET SUVr into Centiloid scale.These images were processed using SPM8 with the standard Centiloid VOIs, following the methods described by Klunk et al., (2015).

GE_AD_C11_DICOM.7z GE_AD_C11_NIFTI.7z GE_AD_F18_DICOM.7z GE_AD_F18_NIFTI.7z GE_AD_MRI_DICOM.7z GE_AD_MRI_NIFTI.7z GE_YHV_C11_DICOM.7z GE_YHV_C11_NIFTI.7z GE_YHV_F18_DICOM.7zx GE_YHV_F18_NIFTI.7z GE_YHV_MRI_DICOM.7z GE_YHV_MRI_NIFTI.7z GE_flutemetamol.xlsx


Please email here for questions regarding this dataset. More details can be found in the following paper:

M. R. Battle et al., UTILITY OF PMOD IMAGE QUANTIFICATION SOFTWARE FOR PROCESSING [11C]PIB AND [18F]FLUTEMETAMOL IMAGES FOR SUVR QUANTITATION ON THE CENTILOID SCALE. Alzheimer’s Dement. J. Alzheimer’s Assoc. 12, P126 (2017).

M. R. Battle et al., Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods. EJNMMI Res. 8, 107. (2018). doi:10.1186/s13550-018-0456-7.

[F-18] Florbetapir Calibration


50-60 minute florbetapir and 50-70 minute PiB dataset (DICOM data)

The Centiloid method (Klunk et al. 2015) was applied to 18F-Florbetapir and 11C-PiB to derive scaling factors required to convert florbetapir SUVr to the Centiloid scale. This dataset consists of 50-60 minute florbetapir, 50-70 minute PiB, and corresponding MRI data for 13 young controls and 33 elderly subjects.

Young Control florbetapir Young Control PiB Young Control MRI Elder subject florbetapir Elder subject PiB Elder subject MRI Patient Demographics Avid_Centiloid_standard_method.xlsx AVID VOIs.zip


Please email here for questions regarding this dataset. More details can be found in the following paper:

M. Navitsky et al., Standardization of Amyloid Quantitation with Florbetapir SUVr to the Centiloid Scale. Alzheimers Dement.

A.D. Joshi, et al. A Semiautomated Method for Quantification of F18 Florbetapir PET Images. J Nucl Med