Centiloid Project


 

Amyloid imaging with positron emission tomography (PET), has produced remarkably consistent qualitative findings across a large number of centers; however, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. A common quantitative output value for beta-amyloid imaging applicable across tracers and methods will allow better comparison of data across sites, ultimately resulting in the application of universal diagnostic and prognostic values.

This has driven the creation of a 100-point scale termed “Centiloid,” which is an average value of zero in “high certainty” amyloid negative subjects and an average of 100 in “typical” Alzheimer’s disease (AD) patients (Klunk et al., 2015). Calibration to the Centiloid scale allows units that are more easily compared across sites. All data used in the Centiloid Project is available for download in the pages below.

Standard PiB (PET or DICOM) data:

[F-18] amyloid tracers:

CALIBRATION OF THE STANDARD PiB METHOD

These data can be used to scale global cortical PiB PET SUVr data to the Centiloid standard scale.

This is the basic dataset that most users will employ when doing Level 2 or Level 3 Centiloid scaling analyses. It consists of all of the AD-100 and YC-0 PiB PET 50-70 min data and the corresponding MR data in both DICOM and nifti formats.


Full Dynamic Dataset Advanced Users File Names and descriptions

This dataset is intended for users who are seeking to scale PiB PET data that is not 50-70 SUVr to the Centiloid scale. This would include dynamic PiB data (e.g., BPND) and SUVr data from a time period other than 50-70 min. This dataset may allow users to do this without acquiring any new PiB PET data. Users who seek to perform a standard Centiloid scaling analysis should use the 50-70 min dataset.

Disclaimer: This data is intended for users already experienced in the use of dynamic PET data. These users should refer to the “CentiloidPETFraming.xls” file as an aid to determining the framing of each subject dataset.


Supplementary Data Advanced Users File Names and descriptions

This is the data described in section 2.1.2 “The standard VOIs” in the Centiloid Project paper (Klunk et al. Alzheimers Dement 2015;11:1-15). This dataset was used to generate the average AD-CTX and average OC-CTX images - the difference between which at 1.05 SUVr units produced the standard cortical target (CTX) VOI.

Please email here for questions regarding the Centiloid Project.

W. E. Klunk et al., The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers. Dement. 11, 1–4 (2015).


Calibration of F-18 Amyloid Tracers


These data are for standardizing F-18 amyloid tracers that have been calibrated to the Centiloid standard scale.


 

[F-18] Florbetaben (FBB) Calibration


50-70 Minute PIB and 90-110 FBB Dataset (dicom data) File Names and descriptions

The Centiloid method was applied on 18F-FBB (FBB) and 11C-PiB (PiB) Ab images to derive the scaling factor required to express FBB tracer binding in Centiloids (CL). This is the basic dataset that users will use to convert FBB PET SUVR into Centiloid scale. It consists of 50-70 min PIB and 90-110 FBB scans from 25 elderly subjects and 10 young controls and the corresponding MR data in dicom.


Please email here for questions regarding this dataset. More details can be found in the following paper:

18F-Florbetaben PET beta-amyloid binding expressed in Centiloids, Rowe, C.C., Doré, V., Jones, G. et al. Eur J Nucl Med Mol Imaging (2017). doi:10.1007/s00259-017-3749-6

[F-18] Flutemetamol Calibration


50-70 Minute PIB/flutemetamol Dataset (NIFTI and DICOM data)  File Names and descriptions

This is the data set that users will use to convert [18F]flutemetamol PET SUVr into Centiloid scale. [18F]flutemetamol and [11C]PiB images were processed using SPM8 with the standard Centiloid VOIs, following the methods described by Klunk et al, (Alzheimers Dement, 2015).

The datasets consists of 50-70 min PIB and 90-110 min [18F] flutemetamol scans from 17 AD Patients and 23 young healthy controls and the corresponding MR data in both NITI and DICOM.

This dataset can be used to convert [18F]flutemetamol PET SUVr into Centiloid scale.These images were processed using SPM8 with the standard Centiloid VOIs, following the methods described by Klunk et al., (2015).


Please email Dr. Chris Buckley or Mr. Mark Battle  for questions regarding this dataset. More details can be found in the following paper:

M. R. Battle et al., UTILITY OF PMOD IMAGE QUANTIFICATION SOFTWARE FOR PROCESSING [11C]PIB AND [18F]FLUTEMETAMOL IMAGES FOR SUVR QUANTITATION ON THE CENTILOID SCALE. Alzheimer’s Dement. J. Alzheimer’s Assoc. 12, P126 (2017).